Ginee Tab(Glu ...
Ginee Tab(Glucosamine Hcl 750 Mg)
General product information
Ginee Tablet (glucosamine 750mg)Glucosamine Hydrochloride vs. Glucosamine Sulfate
There is discussion over which of the two glucosamine salts, hydrochloride
or sulfate, is preferred for the of Osteoarthritis treatment.
The answer is straightforward - both salts, in the pure form, deliver equally effective amounts of the desired glucosamine to joint Cartilage. If there is a preference, it should be based on relative purity and economics. Historically, the sulfate was used for the initial European clinical studies because it was made available for that purpose by an Italian pharmaceutical company which had a proprietary position on the , it was to their marketing advantage to supply only the sulfate and ignore the hydrochloride. The original researchers, however, clearly relate all of the observed benefits relative to osteoarthritis to 'glucosamine' not to the ingested, glucosamine sulfate is fully ionized in the stomach by the relatively strong concentration of hydrochloric acid (pH 1 - 3)naturally present. As a result, glucosamine ions and sulfate ions are thoroughly mixed with an over whel- ming number of chloride and hydrogen ions from the hydrochloric acid. If you could stop at this point and recover the glucosamine salt, you would get 99% glucosamine hydrochloride as the sulfate is essentially lost due to its very low concentration relative to the extremely large amount of hydrochloric acid present. As reported by Setnikar1, 54% of the glucosamine that moves into the small intestine (pH 6.8) exists in its un-ionized, amine form (not a salt at all) while 46% is ionized (the amine group is protenated and positively charged). In the blood at pH 7.4, 75% of the glucosamine is present as the neutral amine while only 25% is ionized. Since ionization or high polarity is usually an obstacle in the crossing of cellular membranes, the ability of glucosamine to exist predominantly in its less polar, un-ionized form in the small intestine and, even more so, in the blood contributes directly to its bioavailability. The specific salt form is relevant only as a convenient delivery vehicle with the proviso that the salt must readily dissolve (ionize) in stomach acid when ingested the HCL and the sulfate equally meet this requirement. The real issue, therefore, becomes one of purity (and stability) Our highly stable Ginee (Glucosamine HCL) is domestically manufactured in an FDA approved, GMP plant and is 99 percent pure with less than 0.1% ash on ignition. On the other hand, pure Glucosamine Sulfate is very hygroscopic and degrades rapidly (goes from white to off-white to tan to brown) when exposed to moisture.To avoid this problem, Glucosamine sulfate, as currently imported, is made from glucosamine HCl by adding either sodium or otassium, sulfate and co-crystallizing the resulting mixture. For this reason, virtually all of the glucosamine sulfate imported into the US is only 80% pure with the remaining 20% being sodium or potassium chloride (this accounts for the high percentage of ash found in the sulfate on ignition). In a dietary upplement market that is under constant government and media scrutiny, purity and stability are key elements for success. There is also the additional question of economics. Because glucosamine sulfate is made from glucosamine hydrochloride, it is significantly more expensive approximately 1.5 times the price of the hydrochloride. The presence of 20% by weight sodium (or potassium) chloride in order to avoid stability problems further dilutes the sulfate and significantly adds to the cost of the sulfate on an active glucosamine basis. Conversely, GINEE (Glucosamine HCl) provides a high purity, stable source of glucosamine that is readily absorbed by the body and is the most cost effective form of glucosamine available.The BAYIR HEMICALS GINEE TABLET (Glucosamine Hydrochloride) to the pharmaceutical, health-nutrition, health markets. FDA approved, GMP plant that manufactures pharmaceutical grade Glucosamine Hydrochloride of the highest quality.
Product Comparison
GINEE
(Glucosamine HCl) Comparative AttributeGlucosamine Sulfate
(NaCl added)
99%Purity
(as the specific salt)80%
83.1%Bio-Active Glucosamine
(as the free base)62.8%
1,500 mgEquivalent Dosage
(Based on Active)1,995 mg
Functionality - Both the hydrochloride and sulfate dissolve (ionize) completely in the stomach's hydrochloric acid which makes all of the glucosamine present, regardless of the source, readily available for absorption in the small intestine. Once absorbed into the blood stream, the glucosamine, independent of the original salt, is equally available to the body. Purity GINEE (GLUCOSAMINE HCL) is highly stable and manufactured to a purity of over 99%. On the other hand,the sulfate is only 80% pure as it manufactured by adding 2 moles of sodium (or potassium) sulfate to Glucosamine Hydrochloride and co-crystallizing the mixture. The resulting product is approximately 20% by weight sodium potassium chloride. Bio-Active Glucosamine - The neutral amino sugar, glucosamine, is the real bio-active material that acts as the precursor to the body's synthesis of glycosaminoglycans, hyaluronate, proteoglycans, and collagen - all the necessary components to repair and maintain healthy cartilage and joint function. Based on the aforementioned purity and the relative molecular weights of glucosamine and each of its salts, simple math shows that GINEE (GLUCOSAMINE HCL) delivers 83.1% active glucosamine while the sulfate supplies only 62.8%. Daily & Monthly Usage - If both products are packaged in 750 mg Equivalent Dosage - The suggested daily dosage is 1,500 mg of GINEES In order to get the equivalent amount of glucosamine found in 1,500 mg of the hydrochloride, you would Need to take 1,995 mg of the sulfate tablets you would have to take 2.66 sulfates tablet daily compared to only 2 GINEE TABLET in order to get the same amount of active glucosamine. On a monthly basis you would need 80 TABLET of sulfate to equal 60 TABLETS GINEE. Packaged 30 TABLETS & 60 TABLETS a bottle, Ginee is the most economic brand in the market and quality is assured from raw material to finish goods because we are the basic Manufacturer of all type of glucosamin.
Ayuginee Tablet
NATURAL CHOICE FOR ARTHRITIS
Composition:
SL no. Sanskrit Name Scientific Name Quantity used
1. Shallaki ( Kunduru ) Niryasa Boswellia serrata extract 250 mg
2. Chingati satva Glucosamine 750 mg
3. Haridra Ghana satva Curcuma longa extract 25 mg
Packing : Bottle filling: 30s and 60 s
Indications: Osteo- Arthritis and other inflammatory conditions of joints.
Dosage: 1 Tablet BID after food.
Features:
Natural choice for Osteoarthritis treatment.
Best Joint Support
Promotes optimal joint function and flexibility with natural ingredients.
Benefits:
AUGINEE contains the connective tissue-supportive nutrient Chingati satva / glucosamine, which provides Essential building blocks for joint cartilage. It has been studied in numerous trials for its ability to maintain and Sustain healthy joint function.
The formulation contains two powerful herbal extracts, Boswellia serrata and Curcuma longa. The joint protective and free radical scavenging properties of these herbs provide a synergy that is complementary to glucosamine in progressively
Supporting enzymatic and metabolic processes that serve to promote optimal joint health and comfort.
Tradition and research join together to create AYUGINEE. Its formula is based on an in-depth study of herbs and Research has shown that the major benefits of Boswellia serrata in promoting healthy joints can be attributed to the Active constituents of the plant known as boswellic acids. The most important components of these compounds are Beta-boswellic acid, acetyl- beta-boswellic acid, 11-keto-beta-boswellic acid and acetyl-11-keto-beta-boswellic acid. Analysis of samples of Boswellia serrata extract showed that the extract contains the major boswellic acids at high Levels, with a total organic acid content of over 70%. Other natural resources. Research has confirmed their effectiveness in the relief of inflammation and other symptoms of osteoarthritis and .These ingredients work in synergy to help relieve symptoms and reduce INEE Tablets MODE OF ACTION
Chingati Satva /Glucosamine is an amino sugar found throughout the body. It is made of glucose and the Ammoniated glutamine combined by the glucosamine synthesis. Since the early 80's, research has shown that Supplementation of glucosamine stimulates the generation of articular tissues: synovial fluids and cartilages.
Durable relief is felt after only two weeks of resin of Boswellia serrata, and Curcumine from Curcuma longa which were demonstrated to act as anti-inflammatory agents in -vivo animal models, were Studied in a set of in -vitro experiments in order to elucidate the mechanism of their beneficial effects. Boswellic Acids were isolated from the gum resin of Boswellia serrata and identified as the active principles. Boswellic acids inhibited the leukotriene synthesis via 5-lipoxygenase, but did not affect the 12-lipoxygenase and the Cyclooxygenase activities. Additionally, boswellic acids did not impair the per oxidation of arachidonic acid by iron and data suggest that boswellic acids are specific, non-red ox inhibitors of leukotriene synthesis either interacting directly with 5-lipoxygenase or blocking its umine inhibited the 5-lipoxygenase activity in rat peritoneal Neutrophils as well as the 12-lipoxygenase and the cyclooxygenase activities in human a cell free Per oxidation system curcumine exerted strong antioxidant activity. Thus, its effects on the deoxy- -- genates are Probably due to its reducing capacity. Rationale of combination: Boswellic acids and glucosamine show synergistic
effect in preclinical anti-inflammatory study in rats SINGH Surjeet (1) ; KHAJURIA Anamika et al, Bioorganic & medicinal chemistry letters 2007, vol. 17, no13, pp. 3706-3711 (6 page(s)) a synergistic effect was observed in chronic inflammatory conditions when two Chemical entities were administered in combination in preclinical study. Scientific References :
1.Srimal, R.C., and Dhawan, B.N. (1985). 'Pharmacological and Clinical Studies on Curcuma Longa,' Hamdard Nat'l. Found. Monograph, New Delhi, India, Section 3B (ii).
2.Chandra, D., and Gupta, S.S. (1972). 'Anti-inflammatory and Anti-arthritic Activity of Volatile Oil of C. Longa,' Ind. J. Med. Res.60:138.
3.Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in Treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial.Phytomedicine. 2003 Jan; 10(1):3-7.
4.Safayhi, H., Mack, T., Sabieraj, J., Anazodo, M.I., Subramanian, L.R.,and Ammon, H.P.T. (1992) Boswellic Acids: Novel, specific, nonredox inhibitors of 5-lipoxygenase. J. Pharmacol. Exp. Ther. 261(3), 1143-1146.
5. Deodars, S.D., et al. (1980). 'Preliminary Studies on Anti-Rheumatic Activity of Cur cumin,' Ind. J. Med. Res. 7:632.
6. Jain, J.P., et al. (1979). 'Clinical Trials of Haridra in Cases of Tamak Swasa and Kasa,' J. Res. Indian. Med. Yoga and . Homeo 14:110.
7. Srivastava, V., et al. (1986). 'Effect of Cur cumin on Platelet Aggregation and Vascular Prostacyclin Synthesis,
' Arzneim. Forsch
8. Deodars, S.D., Sethi, R. Srimal. R.C. Preliminary study on antirheumatic activity of cur cumin (diferoyl methane). Indian . J Med Res 1980; 71:632-34.
9. Atal, C., Zutshi, U., Rao, P. Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs. Journal of . Ethno pharmacology 1981; 4:229-232.
10. Long-term effects of glucosamine on osteoarthritis progression: A randomized, placebo-controlled clinical Trial, ' . . Lancet, 2001 Jan 27; 357(9252):251-6.
Ginee Tablet (glucosamine 750mg)
Glucosamine Hydrochloride vs. Glucosamine Sulfate
There is discussion over which of the two glucosamine salts, hydrochloride
or sulfate, is preferred for the of Osteoarthritis treatment.
The answer is straightforward - both salts, in the pure form, deliver equally effective amounts of the desired glucosamine to joint Cartilage. If there is a preference, it should be based on relative purity and economics. Historically, the sulfate was used for the initial European clinical studies because it was made available for that purpose by an Italian pharmaceutical company which had a proprietary position on the , it was to their marketing advantage to supply only the sulfate and ignore the ydrochloride. The original researchers, however, clearly relate all of the observed benefits relative to osteoarthritis to 'glucosamine' not to the ingested, glucosamine sulfate is fully ionized in the stomach by the relatively strong concentration of hydrochloric acid (pH 1 - 3)naturally present. As a result, glucosamine ions and sulfate ions are thoroughly mixed with an over whel- ming number of chloride and hydrogen ions from the hydrochloric acid. If you could stop at this point and recover the glucosamine salt, you would get 99% glucosamine hydrochloride as the sulfate is essentially lost due to its very low concentration relative to the extremely large amount of hydrochloric acid present. As reported by Setnikar1, 54% of the glucosamine that moves into the small intestine (pH 6.8) exists in its un-ionized, amine form (not a salt at all) while 46% is ionized (the amine group is protenated and positively charged). In the blood at pH 7.4, 75% of the glucosamine is present as the neutral amine while only 25% is ionized. Since ionization or high polarity is usually an obstacle in the crossing of cellular membranes, the ability of glucosamine to exist predominantly in its less polar, un-ionized form in the small intestine and, even more so, in the blood contributes directly to its bioavailability. The specific salt form is relevant only as a convenient delivery vehicle with the proviso that the salt must readily dissolve (ionize) in stomach acid when ingested the HCL and the sulfate equally meet this requirement. The real issue, therefore, becomes one of purity (and stability) Our highly stable Ginee (Glucosamine HCL) is domestically manufactured in an FDA approved, GMP plant and is 99 percent pure with less than 0.1% ash on ignition. On the other hand, pure Glucosamine Sulfate is very hygroscopic and degrades rapidly (goes from white to off-white to tan to brown) when exposed to moisture.To avoid this problem, Glucosamine sulfate, as currently imported, is made from glucosamine HCl by adding either sodium or otassium, sulfate and co-crystallizing the resulting mixture. For this reason, virtually all of the glucosamine sulfate imported into the US is only 80% pure with the remaining 20% being sodium or potassium chloride (this accounts for the high percentage of ash found in the sulfate on ignition). In a dietary upplement market that is under constant government and media scrutiny, purity and stability are key elements for success. There is also the additional question of economics. Because glucosamine sulfate is made from glucosamine hydrochloride, it is significantly more expensive approximately 1.5 times the price of the hydrochloride. The presence of 20% by weight sodium (or potassium) chloride in order to avoid stability problems further dilutes the sulfate and significantly adds to the cost of the sulfate on an active glucosamine basis. Conversely, GINEE (Glucosamine HCl) provides a high purity, stable source of glucosamine that is readily absorbed by the body and is the most cost effective form of glucosamine available.The BAYIR HEMICALS GINEE TABLET (Glucosamine Hydrochloride) to the pharmaceutical, health-nutrition, health markets. FDA approved, GMP plant that manufactures pharmaceutical grade Glucosamine Hydrochloride of the highest quality.
Product Comparison
GINEE
(Glucosamine HCl) Comparative AttributeGlucosamine Sulfate
(NaCl added)
99%Purity
(as the specific salt)80%
83.1%Bio-Active Glucosamine
(as the free base)62.8%
1,500 mgEquivalent Dosage
(Based on Active)1,995 mg
Functionality - Both the hydrochloride and sulfate dissolve (ionize) completely in the stomach's hydrochloric acid which makes all of the glucosamine present, regardless of the source, readily available for absorption in the small intestine. Once absorbed into the blood stream, the glucosamine, independent of the original salt, is equally available to the body. Purity GINEE (GLUCOSAMINE HCL) is highly stable and manufactured to a purity of over 99%. On the other hand,the sulfate is only 80% pure as it manufactured by adding 2 moles of sodium (or potassium) sulfate to Glucosamine Hydrochloride and co-crystallizing the mixture. The resulting product is approximately 20% by weight sodium potassium chloride. Bio-Active Glucosamine - The neutral amino sugar, glucosamine, is the real bio-active material that acts as the precursor to the body's synthesis of glycosaminoglycans, hyaluronate, proteoglycans, and collagen - all the necessary components to repair and maintain healthy cartilage and joint function. Based on the aforementioned purity and the relative molecular weights of glucosamine and each of its salts, simple math shows that GINEE (GLUCOSAMINE HCL) delivers 83.1% active glucosamine while the sulfate supplies only 62.8%. Daily & Monthly Usage - If both products are packaged in 750 mg Equivalent Dosage - The suggested daily dosage is 1,500 mg of GINEES In order to get the equivalent amount of glucosamine found in 1,500 mg of the hydrochloride, you would Need to take 1,995 mg of the sulfate tablets you would have to take 2.66 sulfates tablet daily compared to only 2 GINEE TABLET in order to get the same amount of active glucosamine. On a monthly basis you would need 80 TABLET of sulfate to equal 60 TABLETS GINEE. Packaged 30 TABLETS & 60 TABLETS a bottle, Ginee is the most economic brand in the market and quality is assured from raw material to finish goods because we are the basic Manufacturer of all type of glucosamin.
Ayuginee Tablet
NATURAL CHOICE FOR ARTHRITIS
Composition:
SL no. Sanskrit Name Scientific Name Quantity used
1. Shallaki ( Kunduru ) Niryasa Boswellia serrata extract 250 mg
2. Chingati satva Glucosamine 750 mg
3. Haridra Ghana satva Curcuma longa extract 25 mg
Packing : Bottle filling: 30s and 60 s
Indications: Osteo- Arthritis and other inflammatory conditions of joints.
Dosage: 1 Tablet BID after food.
Features:
Natural choice for Osteoarthritis treatment.
Best Joint Support
Promotes optimal joint function and flexibility with natural ingredients.
Benefits:
AUGINEE contains the connective tissue-supportive nutrient Chingati satva / glucosamine, which provides Essential building blocks for joint cartilage. It has been studied in numerous trials for its ability to maintain and Sustain healthy joint function.
The formulation contains two powerful herbal extracts, Boswellia serrata and Curcuma longa. The joint protective and free radical scavenging properties of these herbs provide a synergy that is complementary to glucosamine in progressively
Supporting enzymatic and metabolic processes that serve to promote optimal joint health and comfort.
Tradition and research join together to create AYUGINEE. Its formula is based on an in-depth study of herbs and Research has shown that the major benefits of Boswellia serrata in promoting healthy joints can be attributed to the Active constituents of the plant known as boswellic acids. The most important components of these compounds are Beta-boswellic acid, acetyl- beta-boswellic acid, 11-keto-beta-boswellic acid and acetyl-11-keto-beta-boswellic acid. Analysis of samples of Boswellia serrata extract showed that the extract contains the major boswellic acids at high Levels, with a total organic acid content of over 70%. Other natural resources. Research has confirmed their effectiveness in the relief of inflammation and other symptoms of osteoarthritis and .These ingredients work in synergy to help relieve symptoms and reduce INEE Tablets MODE OF ACTION
Chingati Satva /Glucosamine is an amino sugar found throughout the body. It is made of glucose and the Ammoniated glutamine combined by the glucosamine synthesis. Since the early 80's, research has shown that Supplementation of glucosamine stimulates the generation of articular tissues: synovial fluids and cartilages.
Durable relief is felt after only two weeks of resin of Boswellia serrata, and Curcumine from Curcuma longa which were demonstrated to act as anti-inflammatory agents in -vivo animal models, were Studied in a set of in -vitro experiments in order to elucidate the mechanism of their beneficial effects. Boswellic Acids were isolated from the gum resin of Boswellia serrata and identified as the active principles. Boswellic acids inhibited the leukotriene synthesis via 5-lipoxygenase, but did not affect the 12-lipoxygenase and the Cyclooxygenase activities. Additionally, boswellic acids did not impair the per oxidation of arachidonic acid by iron and data suggest that boswellic acids are specific, non-red ox inhibitors of leukotriene synthesis either interacting directly with 5-lipoxygenase or blocking its umine inhibited the 5-lipoxygenase activity in rat peritoneal Neutrophils as well as the 12-lipoxygenase and the cyclooxygenase activities in human a cell free Per oxidation system curcumine exerted strong antioxidant activity. Thus, its effects on the deoxy- -- genates are Probably due to its reducing capacity. Rationale of combination: Boswellic acids and glucosamine show synergistic
effect in preclinical anti-inflammatory study in rats SINGH Surjeet (1) ; KHAJURIA Anamika et al, Bioorganic & medicinal chemistry letters 2007, vol. 17, no13, pp. 3706-3711 (6 page(s)) a synergistic effect was observed in chronic inflammatory conditions when two Chemical entities were administered in combination in preclinical study. Scientific References :
1.Srimal, R.C., and Dhawan, B.N. (1985). 'Pharmacological and Clinical Studies on Curcuma Longa,' Hamdard Nat'l. Found. Monograph, New Delhi, India, Section 3B (ii).
2.Chandra, D., and Gupta, S.S. (1972). 'Anti-inflammatory and Anti-arthritic Activity of Volatile Oil of C. Longa,' Ind. J. Med. Res.60:138.
3.Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in Treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial.Phytomedicine. 2003 Jan; 10(1):3-7.
4.Safayhi, H., Mack, T., Sabieraj, J., Anazodo, M.I., Subramanian, L.R.,and Ammon, H.P.T. (1992) Boswellic Acids: Novel, specific, nonredox inhibitors of 5-lipoxygenase. J. Pharmacol. Exp. Ther. 261(3), 1143-1146.
5. Deodars, S.D., et al. (1980). 'Preliminary Studies on Anti-Rheumatic Activity of Cur cumin,' Ind. J. Med. Res. 7:632.
6. Jain, J.P., et al. (1979). 'Clinical Trials of Haridra in Cases of Tamak Swasa and Kasa,' J. Res. Indian. Med. Yoga and . Homeo 14:110.
7. Srivastava, V., et al. (1986). 'Effect of Cur cumin on Platelet Aggregation and Vascular Prostacyclin Synthesis,
' Arzneim. Forsch
8. Deodars, S.D., Sethi, R. Srimal. R.C. Preliminary study on antirheumatic activity of cur cumin (diferoyl methane). Indian . J Med Res 1980; 71:632-34.
9. Atal, C., Zutshi, U., Rao, P. Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs. Journal of . Ethno pharmacology 1981; 4:229-232.
10. Long-term effects of glucosamine on osteoarthritis progression: A randomized, placebo-controlled clinical Trial, ' . . Lancet, 2001 Jan 27; 357(9252):251-6.
for arthritis ,cartilage